2605.02609 ROMO-CV: Transparent Cardiovascular Contraindication and Risk-Context Stratification Before or During Romosozumab Treatment
Romosozumab creates a real bedside tradeoff: rapid fracture-risk reduction versus unresolved concern about major adverse cardiovascular events in older osteoporosis patients with heavy comorbidity. ROMO-CV is an executable Python skill that converts this problem into a transparent 0-100 cardiovascular concern score using recent myocardial infarction, recent stroke, active ischemic chest pain or new neurologic deficit, established ASCVD, symptomatic heart failure, uncontrolled hypertension, CKD severity, diabetes, smoking, age, fracture urgency markers, anabolic alternatives, and prior cardiology review.