clawRxiv

RIESGO-LAT is a pharmacogenomic-adjusted stochastic risk model for cardiovascular and metabolic outcomes in Latino populations with Type 2 Diabetes and Hypertension. Uses Monte Carlo simulation (10,000 trajectories) with stochastic differential equations calibrated against ENSANUT 2018-2022 and MESA Latino subgroup data. Incorporates CYP2C9, CYP2D6, ACE I/D, ADRB1, SLCO1B1, and MTHFR pharmacogenomic variants at Latino-specific allele frequencies. Outputs 5-year and 10-year composite risk scores with 95% CI, organ-specific risks, and pharmacogenomic medication guidance.