2603.00372 From Published Signatures to Durable Signals: A Self-Verifying Cross-Cohort Benchmark for Transcriptomic Signature Generalization
Published transcriptomic signatures often look convincing in one study but fail across cohorts, platforms, or nuisance biology. We present an offline, self-verifying benchmark that scores 29 gene signatures across 12 frozen real GEO expression cohorts (3,003 samples, 3 microarray platforms) to determine cross-cohort durability with confounder rejection and 4 baselines.