ANEMIA-IMMUNE stratifies anemia in autoimmune disease by combining hemoglobin severity, MCV, ferritin, transferrin saturation, CRP, reticulocytes, kidney function, bleeding signals, hemolysis signals, and myelosuppressive drugs into a transparent 0-100 concern score and phenotype label. The implementation is executable Python and is intended to support differential diagnosis of iron deficiency, inflammation/CKD-pattern anemia, mixed anemia, and probable marrow-suppression/hemolysis context.
LEF-WASH is a transparent clinical heuristic for reproductive-safety triage when leflunomide is active, recently stopped, or being cleared before conception in rheumatic and autoimmune disease. The bedside problem is not whether the drug was merely discontinued, but whether cholestyramine washout occurred, whether teriflunomide clearance below 0.
Romosozumab creates a real bedside tradeoff: rapid fracture-risk reduction versus unresolved concern about major adverse cardiovascular events in older osteoporosis patients with heavy comorbidity. ROMO-CV is an executable Python skill that converts this problem into a transparent 0-100 cardiovascular concern score using recent myocardial infarction, recent stroke, active ischemic chest pain or new neurologic deficit, established ASCVD, symptomatic heart failure, uncontrolled hypertension, CKD severity, diabetes, smoking, age, fracture urgency markers, anabolic alternatives, and prior cardiology review.
ANIFRO-HZ is an executable, transparent clinical decision-support skill for stratifying herpes zoster concern in systemic lupus erythematosus during or soon after anifrolumab exposure. The bedside problem is not only knowing that zoster risk exists, but recognizing when glucocorticoids, lymphopenia, nephritis-level co-immunosuppression, absent recombinant zoster vaccination, and early symptom patterns create a treatment context that should alter monitoring or escalation.
## Abstract
Anticoagulation in antiphospholipid syndrome (APS) remains clinically contentious because the convenience of direct oral anticoagulants (DOACs) is not matched by uniform safety across APS phenotypes. The central bedside problem is not whether DOACs are ever usable, but whether a given patient sits in a high-risk phenotype where DOAC exposure is especially unfavorable.
Denosumab discontinuation creates a distinctive clinical hazard: vertebral-fracture risk can rebound rapidly when treatment is delayed or stopped without sequential antiresorptive therapy. This problem is especially relevant in rheumatology and glucocorticoid-treated osteoporosis, where missed injections may go unnoticed until new back pain or clustered vertebral fractures emerge.
RA-MODEL is an executable Python skill that consolidates standard rheumatoid arthritis disease-activity and function indices into one transparent longitudinal workflow. It computes DAS28-CRP, DAS28-ESR, CDAI, SDAI, Boolean remission, HAQ-DI, RAPID3, and a treat-to-target summary across serial visits.
Visual ischemic complications of giant cell arteritis (GCA) are among the most time-sensitive emergencies in rheumatology and ophthalmology because permanent vision loss can occur before diagnostic certainty is complete. GCA-VISION is an executable dependency-free Python skill that converts this bedside problem into a transparent 0-100 ocular ischemia risk-context score.
HCQ-QT is an executable Python skill for transparent QT-prolongation risk-context stratification before or during hydroxychloroquine therapy in rheumatic and autoimmune disease. It weights baseline QTc, sex-age context, kidney function, potassium and magnesium status, structural and arrhythmic cardiac history, bradycardia, concomitant QT-prolonging drugs, hydroxychloroquine dose intensity, and syncope or palpitations into a 0-100 concern score.
Osteonecrosis is a clinically meaningful but often underrecognized complication of systemic lupus erythematosus (SLE), especially after repeated pulse methylprednisolone exposure or sustained high cumulative glucocorticoid burden. The diagnostic problem is practical: early hip or groin pain may be normalized until structural injury is advanced, while the real risk context was created earlier by nephritis, steroid intensity, vascular-metabolic factors, and thrombosis biology.
Gene regulatory networks (GRNs) encode the logic of cellular decision-making, with attractors representing stable cell states and feed-forward loops (FFLs) providing signal processing functions. We present GeneRegulatoryNetworkEngine, a pure-Python pipeline for GRN analysis.
CAR-T cell therapy has revolutionized treatment of hematologic malignancies, but solid tumor efficacy remains limited by antigen heterogeneity, T cell exhaustion, and immunosuppressive microenvironments. We present CARTCellEngine, a pure-Python ODE pipeline for CAR-T cell therapy modeling.
Cytokine signaling through NF-κB and JAK-STAT pathways coordinates immune responses, inflammation, and cell fate decisions. We present CytokineSignalingEngine, a pure-Python ODE-based pipeline for cytokine signaling dynamics.
Protein phosphorylation is the most prevalent post-translational modification, regulating virtually all cellular processes. We present PhosphoproteomicsEngine, a pure-Python pipeline for phosphoproteomic data analysis.
Chromatin accessibility measured by ATAC-seq reveals the regulatory landscape of the genome, identifying active enhancers, promoters, and transcription factor binding sites. We present ChromatinAccessibilityEngine, a pure-Python pipeline for ATAC-seq analysis.
Somatic copy number alterations (SCNAs) are ubiquitous in cancer, driving oncogene amplification and tumor suppressor deletion. We present CopyNumberEngine, a pure-Python pipeline for copy number analysis from whole-genome sequencing.
Protein ubiquitination is a versatile post-translational modification regulating protein degradation, DNA repair, signal transduction, and cell cycle progression. We present ProteinUbiquitinationEngine, a pure-Python pipeline for ubiquitin system analysis.
Neurogenomics integrates genomic, transcriptomic, and epigenomic data to understand brain function and neurological disease. We present NeurogenomicsEngine, a pure-Python pipeline for brain transcriptomics analysis.
Mendelian randomization (MR) uses genetic variants as instrumental variables to infer causal effects of exposures on outcomes, avoiding confounding in observational studies. We present MendelianRandomizationEngine, a pure-Python pipeline for two-sample MR analysis.
Metabolic flux analysis quantifies the flow of metabolites through biochemical reaction networks, enabling prediction of cellular metabolic phenotypes. We present MetabolicFluxEngine, a pure-Python pipeline for constraint-based metabolic modeling.