AI agents often misread unfamiliar repositories by over-trusting directory names, partial file reads, and first-pass hypotheses. We present `nexus-mapper`, an executable workflow for building a persistent repository knowledge base that later AI sessions can load before making cross-module decisions.
Graph neural networks (GNNs) demonstrate remarkable performance on node classification tasks but suffer from poor scalability: sampling large neighborhoods results in exponential neighborhood explosion, while full-batch training requires entire graphs in GPU memory. We propose mini-batch training with historical embeddings (MBHE), which combines neighbor sampling with a cache of historical node embeddings from previous training iterations.
Diffusion models have achieved remarkable generative capability but require massive computational resources for inference. The U-Net backbone that drives diffusion quality contains 860M parameters in Stable Diffusion 1.
Neural language models demonstrate strong performance on code generation tasks, yet their outputs frequently contain syntactic errors that prevent compilation or execution. We propose a grammar-aware beam search algorithm that enforces syntactic constraints during decoding, eliminating entire classes of errors during generation rather than post-processing.
Sparse reward environments remain a fundamental challenge in reinforcement learning, requiring agents to explore extensively before obtaining meaningful learning signals. We investigate potential-based reward shaping (PBRS) as a systematic approach to accelerate convergence in sparse-reward tasks while maintaining theoretical optimality guarantees.
Zero-shot missense variant scoring with protein language models typically reduces mutation effects to sequence likelihood alone, leaving mutation-induced changes in hidden-state geometry unused. SpectralBio tests whether **local full-matrix covariance displacement** in ESM2 hidden states—capturing both diagonal variance shifts and off-diagonal correlation reorganization—contributes complementary pathogenicity signal, operationalized as a **TP53-first executable benchmark with frozen verification contract** (`tolerance = 0.
Do NAD+ precursors (NMN and NR) lower blood pressure? The answer depends on how you analyze 2-3 small randomized trials.
Solid-tumor cell therapy is often limited not by lack of tumor-associated antigens, but by off-tumor toxicity, patchy tumor coverage, and the need for contextual recognition. We present an offline, self-verifying workflow that ranks single-antigen and logic-gated cell-therapy leads from compact vendored snapshots of TCGA-style tumor RNA (`OV`, `PAAD`, `STAD`), Human Protein Atlas normal RNA and protein, adult healthy single-cell expression, and TISCH2-style tumor single-cell evidence.
We built an AMP deployability scorer integrating activity, physiological robustness, and liability features from the APD database. On a standard benchmark, it achieves AUROC 0.
We present a deterministic, offline target-prioritization workflow that ranks single-antigen cell-therapy leads only after passing explicit safety filters against bulk-normal RNA, bulk-normal protein, and adult healthy single-cell expression data. The workflow operates on compact frozen snapshots covering five epithelial solid tumor types (ovarian, pancreatic, gastric, hepatocellular, lung adenocarcinoma) with nine candidate surface antigens and three independent safety data layers.
Reversal-based geroprotector retrieval from LINCS transcriptomic signatures is dominated by confounders: across 1,170 DrugBank compounds scored against a frozen ageing query, 99.6% are better explained by inflammation, proliferation suppression, cell cycle arrest, or other non-longevity programs than by a clean rejuvenation signal.
Gene-set overlap against longevity databases is widely used to interpret transcriptomic signatures, but overlap alone cannot distinguish stable classifications from brittle ones, program-specific signals from generic enrichment, or genuine longevity biology from confounders such as inflammation, hypoxia, or apoptosis. We present a pipeline that classifies human gene signatures into aging-like, dietary-restriction-like, senescence-like, mixed, or unresolved states using vendored HAGR reference sets, then stress-tests each call through three certificates with explicit pass/fail thresholds: claim stability (>= 80% preservation across 7+ perturbations), adversarial specificity (>= 67% winner preservation, margin >= 0.
DrugAge contains many promising lifespan-extension results, but striking effects in isolated experiments do not automatically become durable scientific claims. We present an offline automated pipeline that turns DrugAge into a robustness-first screen for longevity interventions.
Prior studies predicting the UN E-Government Development Index (EGDI) suffer from circularity — using internet penetration and education metrics that are direct EGDI sub-index inputs. We explain EGDI using four indicators with zero sub-component overlap: log GDP per capita, Corruption Perceptions Index, urbanization, and government expenditure.
We explain UN E-Government Development Index (EGDI) scores using four indicators with zero EGDI sub-component overlap: log GDP per capita, corruption perceptions, urbanization, and government expenditure. Internet penetration and schooling are excluded as they are direct EGDI sub-index inputs.
We present an executable workflow that explains UN E-Government Development Index (EGDI) scores using four socioeconomic indicators deliberately chosen to avoid overlap with EGDI sub-components: GDP per capita, corruption perceptions, urbanization, and government expenditure. Internet penetration and schooling are excluded because they are direct EGDI sub-index inputs.
We present an executable workflow that explains UN EGDI scores from four socioeconomic indicators deliberately chosen to avoid overlap with EGDI sub-components: GDP per capita, corruption perceptions, urbanization, and government expenditure. Internet penetration and schooling are excluded because they are direct EGDI inputs.
How much of a country's digital governance maturity is explained by its socioeconomic development level? We train a Random Forest model on UN EGDI scores using four indicators that do not overlap with EGDI components — GDP per capita, corruption perceptions index, urbanization, and government expenditure — deliberately excluding internet penetration and schooling (which are EGDI sub-index inputs) to avoid circularity.
The UN E-Government Development Index (EGDI) measures digital governance maturity biennially for 193 countries, creating a two-year measurement gap. We train a Random Forest model on six publicly available socioeconomic indicators (GDP per capita, internet penetration, mean years of schooling, corruption perceptions index, urbanization rate, government expenditure as percentage of GDP) to predict EGDI scores.
We contribute a Monte Carlo simulation tool for government AI investment appraisal addressing three gaps in existing approaches. First, a tiered algorithmic risk model with costs scaled as percentages of investment (not hardcoded), distinguishing routine fairness audits (20% annual, 0.