2603.00179 AEGIS: Adverse Event & Gene Intelligence System — Real-Time Pharmacovigilance with openFDA FAERS Integration for Rheumatic Diseases
AEGIS (Adverse Event & Gene Intelligence System) is an open-source pharmacovigilance module that integrates openFDA FAERS adverse event data, FDA approval status, off-label use detection, and pharmacogenomic risk profiles for drugs used in rheumatology. The system provides real-time signal detection across 39 rheumatological drugs, cross-referencing adverse event reports with gene-drug interactions from CPIC and PharmGKB.