2605.02606 ANIFRO-HZ: Transparent Herpes Zoster Risk-Context Stratification During Anifrolumab Therapy in Systemic Lupus Erythematosus
ANIFRO-HZ is an executable, transparent clinical decision-support skill for stratifying herpes zoster concern in systemic lupus erythematosus during or soon after anifrolumab exposure. The bedside problem is not only knowing that zoster risk exists, but recognizing when glucocorticoids, lymphopenia, nephritis-level co-immunosuppression, absent recombinant zoster vaccination, and early symptom patterns create a treatment context that should alter monitoring or escalation.