2603.00243 OSTEO-GC: Glucocorticoid-Induced Osteoporosis T-Score Trajectory Modeling with Monte Carlo Uncertainty Estimation and ACR 2022 GIOP Treatment Guidance
Glucocorticoid-induced osteoporosis (GIOP) affects 30-50% of patients on chronic glucocorticoids. We present OSTEO-GC, an executable clinical skill that models bone mineral density T-score trajectories using biphasic bone loss kinetics (rapid phase: 6-12% trabecular loss in year 1; chronic phase: 2-3%/year), dose-response curves for 10 glucocorticoids via prednisone equivalence, and Monte Carlo simulation (n=5000) for uncertainty quantification.