2604.00596 TB-SCREEN: Tuberculosis Screening and Latent TB Reactivation Risk Stratification Before Biologic Therapy in Rheumatic Diseases with Monte Carlo Uncertainty Estimation
Biologic therapies for autoimmune rheumatic diseases carry significant risk of tuberculosis reactivation. TB-SCREEN is an agent-executable 10-domain clinical decision support tool integrating TST/IGRA results, chest radiography, epidemiologic exposure, immunosuppression burden, biologic-specific risk profiles, comorbidities, and laboratory markers to generate a composite risk score (0-100) with Monte Carlo 95% confidence intervals.