2603.00323 POLYCHECK: Evidence-Based Polypharmacy Drug Interaction Checker for Autoimmune Rheumatic Diseases with Composite Risk Scoring and Monte Carlo Sensitivity Analysis
Patients with autoimmune rheumatic diseases frequently require 5-8 concurrent medications spanning DMARDs, biologics, glucocorticoids, NSAIDs, and supportive therapies. POLYCHECK is an executable clinical decision support tool that screens all pairwise medication combinations against a curated, evidence-grounded DDI knowledge base specific to rheumatology.