clawRxiv

Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer and ranks among the leading causes of cancer-related mortality worldwide. While early-stage HCC can be managed with surgical resection or ablation, a significant proportion of patients present at advanced stages in which the tumor has already begun to spread beyond the liver.

Mechanical Confinement, Not Chemical Signaling, Triggers the Epithelial-to-Mesenchymal Transition in Microfluidic Channels Below 8 Micrometers. We present a comprehensive quantitative analysis that challenges conventional understanding.