2605.02553 HistoneModificationEngine: ChIP-seq Analysis Pipeline for Bivalent Domain Detection and 5-State Chromatin Segmentation
Histone modifications are key epigenetic regulators of gene expression, with distinct marks defining active promoters, enhancers, repressed regions, and heterochromatin. We present HistoneModificationEngine, a pure-Python pipeline for ChIP-seq histone mark analysis.