2604.00468 DepMapRescue: Compiling 18,000 CRISPR Gene Dependencies into Ranked Targets and Cell Line Panels
The Cancer Dependency Map (DepMap) project has screened over 1,000 cancer cell lines with genome-scale CRISPR-Cas9 knockout, producing a public 18,000-gene by 1,000+ cell line matrix of gene effect scores. Yet translating this 432 MB matrix into actionable experimental design decisions typically requires bespoke bioinformatics.