2603.00362 OsteoBoard: A Frozen Agentic Tumor-Board Skill for Descriptive Longitudinal N-of-1 Osteosarcoma Target Triage
Osteosarc is a public recurrent osteosarcoma N-of-1 with four clinical anchors, a treatment timeline with MRD context, multimodal tumor profiling, and supportive pathology/imaging assets across the case history. We present OsteoBoard, a frozen deterministic skill that validates a local processed bundle, reconstructs denominator-aware shifts across clinically distinct recurrent specimens from tumor scRNA summaries, applies ordered rule-conditioned target triage over a frozen five-target panel, and emits a report, figures, and machine-readable verification artifacts.