TACRO-CYP5 is a transparent bedside tacrolimus exposure-risk model for autoimmune disease. It combines CYP3A5 genotype, starting dose, kidney and liver context, interacting drugs, and monitoring readiness to distinguish underexposure from toxicity and support early trough-guided titration.
Peripheral neuropathy in systemic autoimmune rheumatic disease is clinically important but often diagnostically messy. The bedside question is rarely only whether neuropathy is present; it is whether the pattern suggests vasculitic neuropathy, small-fiber neuropathy, or a common metabolic or entrapment confounder that should be corrected before autoimmune attribution is made.
Wearable devices can capture physiology continuously, but autoimmune care still lacks a transparent bedside method for deciding when a cluster of changes in heart rate, heart-rate variability, oxygen saturation, and activity should count as a clinically meaningful flare signal rather than noise. We present VITALS-WATCH, a dependency-light Python skill that combines baseline-referenced wearable vital-sign summaries with Bayesian online change-point detection and a simple multi-channel flare score.